1) Sood, U.; Müller, M.; Lan, T.; Garg, G.; Singhvi, N.; Hira, P.; Singh, P.; Nigam, A.; Verma, M.; Lata, P.; Kaur, H.; Kumar, A.; Rawat, C. D.; Lal, S.; Aldrich, C.; Bechthold, A.; Lal, R. Amycolatopsis Mediterranei: A Sixty-Year Journey from Strain Isolation to Unlocking Its Potential of Rifamycin Analogue Production by Combinatorial Biosynthesis. Journal of Natural Products. [PDF]

2023

11) Nikolaienko R, Bovo E, Yuen SL, Treinen LM, Berg K, Aldrich CC, Thomas DD, Cornea RL, Zima AV. New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping. Biophysical Journal. [PDF]

10) Xie M, Ganapathy US, Lan T, Osiecki P, Sarathy JP, Dartois V, Aldrich CC, Dick T. ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate. Antimicrob Agents Chemotherapy.  [PDF]

9) Roopnarine O, Yuen SL, Thompson AR, Roelike LN, Rebbeck RT, Bidwell PA, Aldrich CC, Cornea RL, Thomas DD. Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators. Scientific Reports. [PDF].

8) Sharma R, Hartman TE, Beites T, Kim JH, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S, Rhee KY, Schnappinger D. Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis. mBio. [PDF]

7) Hegde P, Orimoloye MO, Sharma S, Engelhart CA, Schnappinger D, Aldrich CC. Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis. Tuberculosis (Edinb). [PDF]

6) Jachak GR, Orimoloye MO, Aldrich CC. Gram Scale Synthesis of Membrane-Active Antibacterial 4-Quinolone Lead Compound. The Journal of Organic Chemistry. [PDF]

5) Sarathy JP, Aldrich CC, Go ML, Dick T. PROTAC antibiotics: the time is now. Expert Opinion on Drug Discovery. [PDF]

4) Sharma S, Jayasinghe YP, Mishra NK, Orimoloye MO, Wong TY, Dalluge JJ, Ronning DR, Aldrich CC. Structural and Functional Characterization of Mycobacterium tuberculosis Homoserine Transacetylase. ACS Infectious Disease. [PDF]

3) Berg K, Hegde P, Pujari V, Brinkmann M, Wilkins DZ, Parish T, Crick DC, Aldrich CC. SAR study of piperidine derivatives as inhibitors of

1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. [PDF]

2) Sullivan MR, McGowen K, Liu Q, Akusobi C, Young DC, Mayfield JA, Raman S, Wolf ID, Moody DB, Aldrich CC, Muir A, Rubin EJ. Biotin-dependent cell envelope remodelling is required for Mycobacterium abscessus survival in lung infection. Nature Microbiology. [PDF]

1) Brody SI, Buonomo JA, Orimoloye MO, Jia Z, Sharma S, Brown CD, Baughn AD, Aldrich CC. A Nucleophilic Activity-Based Probe Enables Profiling of PLP-

Dependent Enzymes. Chembiochem. [PDF]

18) Bidwell PA, Yuen SL, Li J, Berg K, Rebbeck RT, Aldrich CC, Roopnarine O, Cornea RL, Thomas DD. A Large-Scale High-Throughput Screen for Modulators of SERCA Activity. Biomolecules. [PDF]

17) Pujari V, Rozman K, Dhiman RK, Aldrich CC, Crick DC. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infectious Disease. [PDF]

16) Sharma S, Hegde P, Panda S, Orimoloye MO, Aldrich CC. Drugging the microbiome: targeting small microbiome molecules. Current Opinion in Microbiology. [PDF]

15) Aldrich CC, Calderón F, Conway SJ, He C, Hooker JM, Huryn DM, Lindsley CW, Liotta DC, Müller CE. Virtual Special Issue: Epigenetics 2022. ACS Chemical Biology. [PDF]

14) Hegde PV, Aragaw WW, Cole MS, Jachak G, Ragunathan P, Sharma S, Harikishore A, Grüber G, Dick T, Aldrich CC. Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents. Bioorganic and Medicinal Chemistry. [PDF]

13) Poudel TN, Panda S, Orimoloye M, Hegde P, Aldrich CC. 1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides. The Journal of Organic Chemistry. [PDF]

12) Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angewandte Chemie International Edition. [PDF]

11) Schultz JR, Costa SK, Jachak GR, Hegde P, Zimmerman M, Pan Y, Josten M, Ejeh C, Hammerstad T, Sahl HG, Pereira PM, Pinho MG, Dartois V, Cheung A, Aldrich CC. Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane- Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria. Journal of Medicinal Chemistry. [PDF]

10) Ratnapriya S, Braun AR, Cervera Benet H, Carlson D, Ding S, Paulson CN, Mishra N, Sachs JN, Aldrich CC, Finzi A, Herschhorn A. Broad Tricyclic Ring

Inhibitors Block SARS-CoV-2 Spike Function Required for Viral Entry. ACS Infectious Diseases. [PDF]

9) Cole MS, Hegde PV, Aldrich CC. β-Lactamase-Mediated Fragmentation: Historical Perspectives and Recent Advances in Diagnostics, Imaging, and

Antibacterial Design. ACS Infectious Diseases. [PDF]

8)Okawa R, Aldrich CC, Ichikawa S. Total synthesis of pseudouridimycin and its epimer via Ugi-type multicomponent reaction. Chemical Communications. [PDF]

7) Saw WG, Leow CY, Harikishore A, Shin J, Cole MS, Aragaw WW, Ragunathan P, Hegde P, Aldrich CC, Dick T, Grüber G. Structural and Mechanistic Insights into Mycobacterium abscessus  Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor. ACS Infectious Diseases. [PDF]

6) Cole MS, Howe MD, Buonomo JA, Sharma S, Lamont EA, Brody SI, Mishra NK, Minato Y, Thiede JM, Baughn AD, Aldrich CC. Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis. Chemistry. [PDF]

5) Escalante DE, Aldrich CC, Ferguson DM. Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides. Molecules. [PDF]

4) Lindsley CW, Liotta DC, Aldrich CC. A Virtual Collection Focused on Antifungal Drug Discovery. ACS Medicinal Chemistry Letters. [PDF]

3) Hegde PV, Howe MD, Zimmerman MD, Boshoff HIM, Sharma S, Remache B, Jia Z, Pan Y, Baughn AD, Dartois V, Aldrich CC. Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). European Journal of Medicinal Chemistry. [PDF]

2) Lindsley CW, Liotta DC, Aldrich CC. A Virtual Collection Focused on Antifungal Drug Discovery. ACS Medicinal Chemistry Letters. [PDF]

1) Zhang J, Singh DP, Ko CY, Nikolaienko R, Wong King Yuen SM, Schwarz JA, Treinen LM, Tung CC, Rožman K, Svensson B, Aldrich CC, Zima AV, Thomas DD, Bers DM, Launikonis BS, Van Petegem F, Cornea RL. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high- throughput screening. Journal of Biological Chemistry. [PDF]